1. Target definition
All tools in the ProteinsPlus server work on a structure of a protein or a nucleic acid.
In the first step, you need to define this structure either by selecting a structure form the
Protein Data Bank (PDB) via its PDB code (e.g. 2ozr) or upload any other structure in PDB format.
Additional ligand molecules can be provided in SDF format.
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2. Tool selection
Afterwards you can select the tool you are interested in. You can choose PoseView either
by selecting it from the drop-down menu or by following the link under the respective tool description.
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3. Trigger calculation
PoseView depicts molecular interactions of a protein and a ligand molecule. Select the
ligand you are interested in by clicking on the ligands structure diagram or typing its unique identifier
(e.g. GG1_H_2008) in the ligand field.
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4. Result
PoseView results in a graphical two-dimensional representation of the protein-ligand-interaction.
You can view the result in the browser and download it as PDF.
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Publications
For additional information on PoseView, please refer to the corresponding publications:
Stierand, K., Maaß, P. C., Rarey, M. (2006). Molecular Complexes at a Glance:Automated Generation of two-dimensional Complex Diagrams. Bioinformatics,22(14):1710-1716.
Stierand, K., Rarey, M. (2010). Drawing the PDB - Protein-Ligand Complexes in two Dimensions. Medicinal Chemistry Letters, 1(9):540-545.